B3314 - The metabolomic profiling of cigarette smoking - 20/05/2019
B number:
B3314
Principal applicant name:
Osama Mahmoud | School of Psychological Science and Integrative Epidemiology Unit (IEU), University of Bristol (United Kingdom)
Co-applicants:
Prof. Marcus Munafo , Professor George Davey Smith
Title of project:
The metabolomic profiling of cigarette smoking
Proposal summary:
It is hypothesized that exposure to cigarette smoking could influence the risk of cardiovascular diseases through direct modification of the lipoprotein profile, lipotoxicity and change in chronic oxidative stress. However, the metabolic profiling of cigarette smoking have not been precisely investigated.
Using the ALSPAC data, this study aims to provide insights into the molecular effect of smoking both in terms of the composition and the concentration of the molecular species affected.
Impact of research:
Assuming that our hypothesis is true, this study will provide novel insights into the metabolic profiling of cigarette smoking in early adulthood. This work thus has the potential to contribute to the growing body of evidence suggesting association of smoking with cardiovascular disease through modification of metabolomics. Of particular interest will be whether we can identify potential mechanisms that are linking smoking exposure to cardiovascular disease.
Date proposal received:
Thursday, 16 May, 2019
Date proposal approved:
Monday, 20 May, 2019
Keywords:
Epidemiology, coronary heart disease and cardiovascular disease., Metabolomics, NMR, Statistical methods, Cardiovascular, Metabolic - metabolism, cigarette smoking