B3298 - Dynamic Changes in DNA Methylation as a Candidate Causal Pathway Between Adolescent Cannabis Exposure and Psychosis - 18/04/2019
B number:
B3298
Principal applicant name:
Randi Schuster | Massachusetts General Hospital/Harvard Medical School (United States of America)
Co-applicants:
Title of project:
Dynamic Changes in DNA Methylation as a Candidate Causal Pathway Between Adolescent Cannabis Exposure and Psychosis
Proposal summary:
The link between cannabis use and psychosis has been robustly documented. However, it is not known whether cannabis escalation in youth at risk for psychosis has a causal putative influence on reduced cognitive and psychiatric functioning, and whether changes in DNA methylation may mechanistically explain this association.
Impact of research:
Early cannabis exposure has become a growing social phenomenon in our society; however, it is occurring in a population that varies with respect to its consequences. Therefore, this study will elucidate critical biological signatures of cannabis exposure in youth vulnerable to schizophrenia. A better understanding of the mechanisms underlying the link between cannabis and psychosis will improve prognosis, diagnosis, treatment and policy.
Date proposal received:
Wednesday, 17 April, 2019
Date proposal approved:
Thursday, 18 April, 2019
Keywords:
Genetics, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Mental health, GWAS, epigenetics, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Cognition - cognitive function, Epigenetics, Genetics, Genome wide association study, Psychology - personality