B3290 - Non-transmitted genetics and genetic nurturing in ALSPAC - 15/04/2019

B number: 
B3290
Principal applicant name: 
Tim Morris | University of Bristol (United Kingdom)
Co-applicants: 
Dr Laurence Howe, Dr Neil Davies, Dr Gibran Hemani, Dr Hannah Sallis
Title of project: 
Non-transmitted genetics and genetic nurturing in ALSPAC
Proposal summary: 

In this project we will investigate the presence of 'genetic nurturing' in ALSPAC across a range of phenotypes including educational attainment, smoking and alcohol intake. We will estimate genetic nurture as the contribution that parental genotype makes to offspring phenotype through expression of the parents phenotype by creating non-transmitted polygenic scores for ALSPAC participants. There is evidence of genetic nurturing effects for educational attainment (Kong et al, 2018) and we intend to extend this work to further phenotypes to assess how genetic nurture may vary across health and social traits. We will also examine a number of phenotypes for which there should be no genetic nurtutring effects (blood pressure, CRP, lipids) as negative control experiments.

Impact of research: 
Academics & non-academic
Date proposal received: 
Monday, 8 April, 2019
Date proposal approved: 
Tuesday, 9 April, 2019
Keywords: 
Genetics, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Fertility/infertility, Mental health, Obesity, Statistical methods, BMI, Childhood - childcare, childhood adversity, Cognition - cognitive function, Genetics, Genomics