B3252 - Genome Wide Association of Study of Adverse Childhood Experiences - 19/02/2019
B number:
B3252
Principal applicant name:
Hannah Sallis | IEU/Psychology
Co-applicants:
Mr Alex Kwong, Dr Varun Warrier, Ms Jazz Croft, Dr Laura Howe, Professor Marcus Munafo
Title of project:
Genome Wide Association of Study of Adverse Childhood Experiences
Proposal summary:
Genome-wide association studies (GWAS) have been instrumental in highlighting associations between genetic variants and 1000s of traits. Adverse Childhood Events (ACEs) are associated with several adverse outcomes in life. We plan to include ALSPAC data from the mothers and the children in a GWAS of Adverse Childhood Events. This will be a big step towards incorporating ALSPAC data into psychiatric genetics. The summary statistics will contain no identifiable information.
Impact of research:
These will be the largest GWAS of ACEs and provide insights into the genetics of ACE
Date proposal received:
Friday, 8 February, 2019
Date proposal approved:
Wednesday, 13 February, 2019
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Mental health, GWAS, Genome wide association study