B3241 - Investigating the causal relationship between allergic disease and psychiatric disorders - 22/01/2019

B number: 
B3241
Principal applicant name: 
Ashley Budu-Aggrey | MRC Integrative Epidemiology Unit, University of Bristol (United Kingdom)
Co-applicants: 
Dr Hannah Sallis, Sally Joyce
Title of project: 
Investigating the causal relationship between allergic disease and psychiatric disorders
Proposal summary: 

Allergic diseases including asthma, hay fever and eczema often occur in the same individuals. Allergic diseases have been reported to be linked with depression and anxiety disorders, which is also a growing health concern. However, it is not yet clear if the allergic diseases cause depression or mental health disorders, or if these have a causal effect on allergic disease. In this project we hope to use a statistical technique called Mendelian Randomization to investigate the relationship between these traits.

Impact of research: 
Date proposal received: 
Friday, 18 January, 2019
Date proposal approved: 
Tuesday, 22 January, 2019
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Allergy, Eczema, Mental health, Respiratory - asthma, Statistical methods, Dermatology, Genetic epidemiology, Mendelian randomisation, Statistical methods