B3232 - Evaluating the impact of early life adiposity on later life disease risk - 18/12/2018

B number: 
B3232
Principal applicant name: 
Tom Richardson | MRC Integrative Epidemiology Unit (United Kingdom)
Co-applicants: 
Ms Katie O Nunain , Dr Eleanor Sanderson, Professor George Davey Smith
Title of project: 
Evaluating the impact of early life adiposity on later life disease risk
Proposal summary: 

The prevalence of childhood obesity is a growing public health concern which is only expected to increase in the forthcoming years1. Previous studies have shown that children who become obese are at much higher risk of disease in later life, such as diabetes, hypertension and coronary heart disease2. Along with lifestyle factors such as physical activity and diet, there is mounting evidence that genetic factors also contribute substantially towards early life adiposity. Research to better understand this genetic component therefore holds considerable potential in terms of preventive strategies.

Impact of research: 
We hypothesise that early life factors will contribute substantially to later life disease risk. The interesting thing will be how much of this appears to be mediated from early life to later life.
Date proposal received: 
Friday, 14 December, 2018
Date proposal approved: 
Tuesday, 18 December, 2018
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation)