B3127 - Maternal caffeine intake during pregnancy An epigenome-wide association study - 06/06/2018

B number: 
Principal applicant name: 
Gemma Sharp | IEU, University of Bristol (UK)
Miss Laura Schellhas
Title of project: 
Maternal caffeine intake during pregnancy: An epigenome-wide association study
Proposal summary: 

Rationale: Animal studies have provided some evidence that maternal caffeine consumption can influence offspring DNA methylation (PMIDs: 22970234, 24475304, 25354728, 25868845, 25868845), but what about humans?

Impact of research: 
Clarifying the association of caffeine intake during pregnancy and offspring methylation at birth in humans
Date proposal received: 
Friday, 1 June, 2018
Genetic epidemiology (including association studies and mendelian randomisation), Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., epigenome-wide association study, Biological samples -e.g. blood, cell lines, saliva, etc., Birth outcomes, Development, Epigenetics, Genetic epidemiology, Genetics, Mothers - maternal age, menopause, obstetrics, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Offspring