B3093 - Traits phenotypes and prognosis of childhood asthma - 29/03/2018

B number: 
Principal applicant name: 
John Henderson | PHS, Bristol Medical School (UK)
Prof Claudia Kuehni, Ben Spycher
Title of project: 
Traits, phenotypes and prognosis of childhood asthma
Proposal summary: 

The proposal is to continue the collaborative work we have been doing with this Swiss group over the past few years. Ben Spycher was a Marie Curie Fellow who worked with ALSPAC data previously. Prof Kuehni leads eth Leicester Asthma Cohorts and has established the Swiss Paediatric Airway Cohort (SPAC). OUr joint objective is to discover influences that determine the onset and progression of asthma in children, how asthma varies between individuals in type and severity and whether we can predict the outcome of asthma using individuals' information. The data in eth Leicester adn Swiss cohorts is complementary to data held in ALSPAC and we have had joint publications where ALSPAC is able to replicate findings in the other cohorts run by the Swiss group.

Impact of research: 
THere have been several attempts to produce an asthma risk score to address the question most parents of wheezy children ask of clinicians. Many of these have reasonable predictive ability but rely on variables that are not routinely measured in clinical practice. If a scoring tool can be developed that has utility in primary care, it will have a major impact on ability to detect children at high risk fo asthma and target them for early intervention.
Date proposal received: 
Thursday, 29 March, 2018
Clinical research/clinical practice, Respiratory - asthma, Statistical methods, Statistical methods