B3083 - Exploring the relationship between bone turnover and serum levels of citrate - 16/03/2018

B number: 
Principal applicant name: 
Jon Tobias | University of Bristol (United Kingdom)
April Hartley, Celia Gregson, Lavinia Paternoster
Title of project: 
Exploring the relationship between bone turnover and serum levels of citrate
Proposal summary: 

Osteoporosis is a metabolic disorder of bone, characterized by increased bone resorption. Serum collagen type 1 cross-linked C-telopeptide (CTX) is increased during bone resorption. In our preliminary metabolomic analysis, which aimed to identify the metabolic consequences of reduced bone turnover in a cohort of adults with high bone mineral density, we identified a positive relationship between serum CTX and NMR-assessed serum citrate levels (unpublished data). Citrate is a component of bone mineral with a potential structural function (Costello et al 2013). We aim to repeat our cross-sectional analysis of the association between serum CTX and serum citrate in both the ALSPAC mothers and adolescents population to determine if this association replicates, firstly in a general population cohort of a similar age, and secondly in a younger population, which would suggest that serum citrate is a novel marker of bone resorption.

Impact of research: 
If serum citrate is associated with bone resorption (CTX), with evidence for a causal association between CTX and citrate, serum citrate could be used as a novel biomarker of osteoporosis and to determine response to osteoporosis therapy.
Date proposal received: 
Thursday, 15 March, 2018
Epidemiology, Bone disorders - arthritis, osteoporosis, GWAS, Mendelian randomisation