B3081 - Helicobacter pylori - Association with cardiovascular disease and cancer - 13/03/2018

B number: 
Principal applicant name: 
Jie Zheng | MRC IEU, University of Bristol (United Kingdom)
Ms Amanda Chong , Dr Evie Stergiakouli, Dr Tom Gaunt
Title of project: 
Helicobacter pylori - Association with cardiovascular disease and cancer
Proposal summary: 

Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonises on the gastric epithelium, and there is clear evidence for its role in causing gastrointestinal diseases. Studies in the United Kingdom have demonstrated the prevalence of H. pylori infection status ranging from 26-66% of the population. There is increasing evidence of the role H. pylori in the development of other diseases, including cardiovascular disease and cancer. Given the relatively high prevalence of infection, this is potentially an important disease risk factor that merits causal investigation. Studies have suggested that infection with H. pylori may affect lipid metabolism, especially with the cardiovascular risk factors: HDL-cholesterol, triglyceride and apolipoproteins. By this mechanism, this could increase the risk of developing atherosclerosis and coronary artery disease. Additionally, studies have postulated that H. pylori could be involved in the development of atherosclerosis by causing vascular inflammation and endothelial dysfunction. H. pylori has also been shown to be involved in gastric carcinogenesis. Through the disruption of epithelial cell functions by H. pylori cytotoxin-associated antigen A (CagA), this oncogenic factor activates oncogenic pathways in these cells and induces epigenetic modifications which play a significant role in initiating carcinogenesis.

Impact of research: 
This research will contribute to the understanding of the causal role of H.pylori in the pathogenesis of cardiovascular disease and cancers, which can then inform public health policies by identifying specific biomarkers and advise novel interventions that can alleviate the risk of developing such diseases.
Date proposal received: 
Tuesday, 13 March, 2018
Genetic epidemiology (including association studies and mendelian randomisation), Cancer, Diabetes, Infection, Cardiovascular disease, GWAS, Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Cardiovascular, Genetic epidemiology, Genome wide association study, Mendelian randomisation