B3078 - Single SNP Replication of rs71564871 - 08/03/2018

B number: 
Principal applicant name: 
Kaitlin Wade | Integrative Epidemiology Unit (United Kingdom)
Title of project: 
Single SNP Replication of rs71564871
Proposal summary: 

A single mutation within the genome (called rs71564871 near a gene called BEND6) has been previously linked to fat distribution in the body, specifically the proportion of fat stored across the waist compared to the hips, in women of the ORCADES study and UK Biobank. Within this study, we want to assess whether this single mutation is similarly related to the same pattern of fat deposition in the Avon Longitudinal Study of Parents and Children.

Impact of research: 
Identifying the genetic contribution of fat distribution to further use in causal analyses to understand how specific regional fat deposition is related to adverse health outcomes.
Date proposal received: 
Thursday, 1 March, 2018
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, GWAS, BMI, Genetic epidemiology, Genetics, Statistical methods