Since the recent publication of large genetic studies to identify genetic risk factors for debilitating psychiatric disorders such as schizophrenia and depression, it has been possible to use this genetic information to study to what extent genetic risk to, for example, schizophrenia or depression predict risk for psychiatric problems prior to the development of clinical disorders. Particularly interesting is to investigate how a child's genetics make him or her more vulnerable to the exposure of stressful life events. Moreover, it is still unclear to what extent this relationship mediates the association between genetic risk and childhood psychiatric problems.