B3072 - BIOMAP - Genome-Environment Interactions in Inflammatory Skin Disease - 06/03/2018

B number: 
Principal applicant name: 
Lavinia Paternoster | MRC IEU (United Kingdom)
Josine Min
Title of project: 
BIOMAP - Genome-Environment Interactions in Inflammatory Skin Disease
Proposal summary: 

Atopic dermatitis (AD) and psoriasis affect a substantial percentage of the population. The mechanisms of disease, endotypes, co-morbidities of these diseases remain poorly understood. There is need to define the heterogeneous and homogeneous aspects of AD and psoriasis and identify the impact of environmental factors, genetic factors and molecular pathways. This will give rise to more precise targeted treatments. The BIOMAP project will bring together existing resources from European cohorts and industry to meet this challenge. ALSPAC, with it's rich longitudinal phenotyping and molecular data is well suited to contribute to this project.

Impact of research: 
This project aims to deliver an improved disease ontology for clinical use, with early biomarker detection of specific disease subtypes. The project also aims to better understand the molecular pathways disrupted in these subtypes, allowing for improved therapeutic treatment, targeted to the right patients. The project involves several academic and industry partners and involves patient groups, for maximal impact of the research findings.
Date proposal received: 
Tuesday, 20 February, 2018
Epidemiology, Inflammatory skin disease, Statistical methods, Dermatology