B3070 - Hypothesis driven analysis of Avon Longitudinal Study early adversity and epigenetic modulation impacting on addiction - 06/03/2018

B number: 
Principal applicant name: 
Femke Buisman-Pijlman | Adelaide Medical School, University of Adelaide (Australia)
Associate Professor Linda Gowing, Dr Murthy Mittinty, Professor Caroline Relton, Professor George Davey Smith
Title of project: 
Hypothesis driven analysis of Avon Longitudinal Study: early adversity and epigenetic modulation impacting on addiction
Proposal summary: 

Why do people who experience early adversity have a higher chance of developing addiction? Do these experiences leave a biological scar? To answer these questions, we will use information from a group of babies, tracked since birth and who are now in their twenties. We will use new statistical methods and information on their early life, DNA and use of alcohol and tobacco as young adults, to identify which specific experiences change their biology and are linked to development of addiction.

Impact of research: 
We will both advance the statical analysis techniques that can be used to investigate causality and provide information on the relative value of specific early factors on methylation and problematic drug and alcohol use (which will be published in high ranking journals). This will provide good opportunities for assessment and early interventions.
Date proposal received: 
Saturday, 17 February, 2018
Mental health - Psychology, Psychiatry, Cognition, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Mental health, Statistical methods, Birth outcomes, Epigenetics, Genetic epidemiology, Parenting, Statistical methods