B3067 - DNA methylation and brain structure - 01/03/2018

B number: 
B3067
Principal applicant name: 
Esther Walton | University of Bristol - IEU
Co-applicants: 
Title of project: 
DNA methylation and brain structure
Proposal summary: 

Studies highlighted the role of genetic variation in brain anatomy (Hibar et al., 2015), but environmental factors might also be involved. The aim of the current study is to investigate to what degree epigenetic variation (DNA methylation) at birth is associated with brain structure across different ages. Secondary analyses aim to follow-up on promising methylation markers at later time points.
This project is part of a collaborative effort within the PACE consortium.

Impact of research: 
Findings could lend novel insights into the epigenetic landscape of brain structure.
Date proposal received: 
Thursday, 15 February, 2018
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Mental health, Medical imaging, Biological samples -e.g. blood, cell lines, saliva, etc., Childhood - childcare, childhood adversity, Cognition - cognitive function, Development, Equipment - MRI, Epigenetics, Offspring