B89 - How do genes modify the prenatal effects of tobacco smoke paracetamol and antioxidant exposures on childhood respiratory outcomes - 01/12/2002
The extent to which oxidant exposures such as tobacco smoke and paracetamol are detrimental, and antioxidants are
beneficial, to lung health, will depend partly on variation in genes involved in antioxidant defences and xenobiotic
metabolism and detoxification. However, few epidemiological studies have explored interactions between such genes
and oxidant/antioxidant exposures on childhood respiratory outcomes.
We will study how relevant gene polymorphisms in the mother and child modify effects of prenatal and postnatal
exposure to tobacco smoke, paracetamol and antioxidants on childhood lung function, wheezing, asthma and
bronchial hyper-responsiveness, in the Avon Longitudinal Study of Parents and Children, a large population-based
birth cohort, which has collected DNA from mothers as well as from children.
Confirmation of interactions between oxidant/antioxidant exposures and gene variants which influence antioxidant
function and xenobiotic toxicity would provide stronger evidence that the effects of the environmental risk factors are
causal, and may provide insights into mechanisms. By increasing our understanding of the early life influences on lung
development we hope to devise new strategies aimed at the primary prevention of lung disease in children and the
optimisation of their respiratory health.