B394 - MTHFR C677T Genotype and Obesity - 11/09/2006

B number: 
Principal applicant name: 
Prof George Davey Smith (University of Bristol, UK)
Prof Shah Ebrahim (London School of Hygiene and Tropical Medicine, UK), Prof Debbie A Lawlor (University of Bristol, UK), Dr Sam Leary (University of Bristol, UK), Dr S J Lewis (University of Bristol, UK), Prof Borge Nordestgaard (University of Copenhagen, Europe), Prof Anne Tybj?rg-Hansen (University of Copenhagen, Europe), Dr Jeppe Zacho (University of Copenhagen, Europe)
Title of project: 
MTHFR C677T Genotype and Obesity.
Proposal summary: 

TheMTHFRTT genotype is associated with an increased frequency of obesity relative to the CC genotype, due to a reduction in availability of folate for methylation observed with this genotype.

We plan to examine the association between the MTHFR genotype in 4 distinct populations within 3 Cohort studies; The British Women's Heart and Health Study, Avon longitudinal study of Parents and Children (2 populations: mothers and children) and Copenhagen City Heart Study.

Date proposal received: 
Monday, 11 September, 2006
Date proposal approved: 
Monday, 11 September, 2006
Diet, Genetics, Obesity, Eating disorders
Primary keyword: