B556 - Relation of adverse psychosocial enviroment to childhood obesity and early puberty as markers of future breast cancer risk - 19/09/2007
B number:
B556
Principal applicant name:
Dejana Braithwaite (University of California, USA)
Co-applicants:
Dr Ken Ong (University of Cambridge, UK), Dr Robert Hiatt (University of California, USA), Dr Pauline Emmett (University of Bristol, UK)
Title of project:
Relation of adverse psychosocial enviroment to childhood obesity and early puberty, as markers of future breast cancer risk
Proposal summary:
Objectives/aims:
- To establish whether markers of adverse psychosocial environment (such as adverse socioeconomic circumstances and stressful life events) are associated with biochemical markers of cortisol metabolism (fasting cortisol levels and urinary excretion of total cortisol metabolites at age 8), central fat patterning (by waist circumference and DXA), and earlier timing of thelarche and menarche (by questionnaire).
- To establish whether these associations are modified by level of physical activity and energy intake.
In addition to providing a test of our proposed stress-body fat-puberty model, the proposed study also has the potential to inform the scientific basis of targeted interventions to reverse the childhood obesity epidemic .
Date proposal received:
Wednesday, 19 September, 2007
Date proposal approved:
Wednesday, 19 September, 2007
Keywords:
Diet, Eating disorders
Primary keyword: