The aim of this proposal is to perform follow-up genotyping of the top associated, listening language comprehension related SNPs within the remaining ALSPAC sample in order to replicate findings from the original ALSPAC genome-wide analysis. The signal at the candidate locus will be represented through common SNPs (r2 less than 0.6; N <= 5) identified from the original ALSPAC genomewide association testing in conjunction with bioinformatics analysis. The selected SNPs will also be subjected to further analysis in another large birth cohort.

No other GWAS on listening language comprehension has been published yet. The recognition and analysis of reliable genetic associates of listening language comprehension in the ALSPAC cohort marks therefore a crucial step towards the identification of biological correlates underlying complex neurocognitive processes such as the understanding of the human language.