The project will involve the genome-wide SNP typing of 6000 ALSPAC children at the CNG Paris on either the Illumina 370K or Illumina 610K SNP chip (depending on costing). If successful, it will mean that the entire cohort of ALSPAC children (for whom DNA is available) will have genome-wide data. The resulting genotypes will be linked with ALSPAC phenotype data and genome-wide association analysis will be performed. Loci showing genome-wide evidence of association (e.g. p less than 5.0 x 10-7) will be followed up in the Raine, Generation R and North Finland birth cohorts depending on the availability of similar phenotype measures. Bristol PIs who are experts in the relevant phenotypic measures will be offered involvement in the analysis, write up, and replication of the findings (e.g. Jon Tobias with the bone mineral density phenotypes).

LOGISTICS:

-Genotyping will be performed by CNG in Paris.

-I will require DNA for genotyping on the Illumina 370K/Illumina 610K platform (which platform is chosen will depend upon cost).

-I will require access to all children's phenotypes contained with the ALSPAC cohort.