Eczema is due to multiple genetic and environmental factors. Although variants in the fillagrin gene have been robustly associated with eczema risk, the vast majority of the genetic variance in this condition remains to be explained. It is our aim to construct a variable indicating whether an individual has ever suffered from eczema and to subject this variable to genome-wide association analysis. Similar data is also available from twins UK (Tim Spector) and Queensland Institute of Medical Research (Nick Martin) and both groups have expressed interest in the possibility of pooling results in a meta-analysis. We will aim to follow up significant associations in the remainder of the ALSPAC cohort and other cohorts for which this measure is available.