B904 - The effects of common genetic variation in the thyroid hormone pathway on growth and development - 07/11/2009
B number:
B904
Principal applicant name:
Peter Nicholas Taylor (University of Bristol, UK)
Co-applicants:
Dr Colin Dayan (University of Bristol, UK), Dr Jon Tobias (University of Bristol, UK), Dr Nic Timpson (University of Bristol, UK), Dr Vijay Panicker (Guru Nanak Hospital, India, ROW)
Title of project:
The effects of common genetic variation in the thyroid hormone pathway on growth and development.
Proposal summary:
We intend to analyse the genotypes TSH-R, PDE8B and DIO1 and their phenotypic effects on bone and neurological and emotional development in the entire ALSPAC cohort, as genotype data are already available from previous work on childhood growth. We will also use GWA data to assess the phenotypic effects of other SNPs known to be reasonable thyroid related candidates, but which do not satisfy strict thresholds for "genomewide significance".
Date proposal received:
Saturday, 7 November, 2009
Date proposal approved:
Saturday, 7 November, 2009
Keywords:
Genetics
Primary keyword: