B994 - Association between SNPs of the IGF Axis against antenatal and postnatal growth - 28/04/2010

B number: 
B994
Principal applicant name: 
Priyakumari Parmar (University of Western Australia, Australia)
Co-applicants: 
Prof Lyle Palmer (Not used 0, Not used 0), Dr Craig Pennell (Not used 0, Not used 0)
Title of project: 
Association between SNPs of the IGF Axis against antenatal and postnatal growth
Proposal summary: 

A manuscript has already been prepared assessing the association between SNPs of the IGF Axis and developmental growth

- 165 SNPs were tagged in Raine as being part of the IGF Axis

- 145 SNPs were used in analyses (20 SNPs were excluded for being inHWE disequilibrium, LD, not genotyped properly less than 80%, and MAF less than 10% in HapMap and Raine)

- Longitudinal analyses for antenatal measures: abdominal circumference, head circumference and ratio of head to abdominal circumference

- Cross-sectional analyses for birth weight, abdominal circumference, head circumference and ponderal index (for measurements taken at birth - on day 2 of life)

- Longitudinal analyses of BMI from year 1 to year 17

- A total of 63 SNPs (out of 145 SNPs) gave at least one significant association (p less than 0.05) with a measure of developmental growth (at birth or antenatal level)

- The following table summarises the analyses

Time

Type of analysis

Outcome

Covariates

Birth

(day 2 of life)

Cross-sectional

Abdominal Circumference

Gestational age, parity, placental weight and maternal diabetes

Head Circumference

Gestational age, parity, placental weight and maternal education

Birth Weight

Gestational age, parity, placental weight

Ponderal Index

Gestational age, placental weight, maternal BMI, maternal and paternal age

Year 1

Cross-sectional

Percentile change in weight

Gestational age, parity, placental function, maternal diabetes and breast-feed

Year 1-18

Longitudinal

BMI

Age

The phenotypic data required for the research in this proposal includes all outcomes and covariates outlined in the table above and are listed below:

  • Data on:
    • Maternal and Paternal age and education
    • Maternal smoking status, BMI, hypertension, diabetes and anemia (during pregnancy)
    • Gestational age
    • Placental weight and function
    • Parity
    • Child breast-feed
    • Gender of child
  • At Birth
      • Abdominal circumference
      • Head circumference
      • Birth weight
      • Ponderal index
  • Postnatal
    • Year One of life
      • Percentile change in weight (since birth)
    • Years One-Eighteen

BMI

Date proposal received: 
Wednesday, 28 April, 2010
Date proposal approved: 
Wednesday, 28 April, 2010
Keywords: 
Genetics
Primary keyword: