Background and objective: The relationship between blood pressure and obesity is well established in both children and adults. Higher blood pressure levels are observed in obese individuals and increased blood pressure levels during childhood strongly predict hypertension in adults. Therefore, isolating genetic variations that may influence blood pressure according to obesity status at childhood might have major implications for public health. Among numerous genetic investigations on blood pressure and hypertension, the most frequent associations concerned the long arm of chromosome 2. Therefore, we in-depth investigated this region, in two independent French normal weight and obese pediatric populations.