B1218 - The relationship between a newly identified functional SNP in the galanin promoter and phenotypic variation in ALSPAC - 29/07/2011
B number:
B1218
Principal applicant name:
Prof David Wynick (University of Bristol, UK)
Co-applicants:
Prof Ian Day (University of Bristol, UK), Prof Jeremy M Tavare (University of Bristol, UK)
Title of project:
The relationship between a newly identified functional SNP in the galanin promoter and phenotypic variation in ALSPAC.
Proposal summary:
This proposal will study the association of the rs2513280 SNP (which is well imputed in the existing ALSPAC GWAS data set) with a range of phenotypic data from the ALSPAC cohort that relate to metabolism, BMI, lipid profile, addiction, depression and anxiety.
Strategically, we see this as the beginning of an important collaboration of significant translational relevance. In the longer term we will wish to expand the study out to other cohorts available in Bristol, but also into a wider examination of other galanin-dependent phenotypes and/or other genes in the galanin signalling pathway.
Date proposal received:
Friday, 29 July, 2011
Date proposal approved:
Friday, 29 July, 2011
Keywords:
Alcohol, Cardiovascular , Genetics, Illicit Drugs, Mental Health, Smoking
Primary keyword: