AIMS: At this time, we aim to 1) study the association between prenatal psychosocial stress and BP in the child in another cohort, 2) study whether the timing of stress indicates a more vulnerable period for programming of BP and 2) study whether the potential higher blood pressure is accompanied by impaired vascular function and alterations in lipid and inflammation markers that would be indicative of a more general cardiometabolic disturbance.

HYPOTHESES: 1) The presence of maternal psychosocial stress is associated with higher systolic and diastolic BP in the offspring. 2) First trimester stress exceeds third trimester stress effects on offspring BP. 3) The presence of maternal psychosocial stress is associated with impaired vascular function and alternations in lipid and inflammation markers in the offspring.

OUTCOME VARIABLES: - Blood-based assays in children at the mean age of 9.9 years. * Lipid markers: high density lipoprotein cholesterol (HDLc); non-high density lipoprotein cholesterol (N-HDLc); triglycerides. * Markers of inflammation: C-reactive protein; interleukin-6 (IL-6). * Apolipoproteins: Apolipoprotein A1 (ApoA1); apolipoprotein B (ApoB). - Vascular measurements in children at the mean age of 10.7 years.Systolic blood pressure (SBP); diastolic blood pressure (DBP); flow-mediated dilatation (FMD); pulse wave velocity (PWV); distensibility coefficient (DC); brachial diameter (BD)