B1252 - Ophthalmic associations of Developmental Co-ordination Disorder - 06/10/2011

B number: 
B1252
Principal applicant name: 
Dr Alexandra Creavin (University of Bristol, UK)
Co-applicants: 
Miss Cathy E M Williams (University of Bristol, UK), Prof Alan Emond (University of Bristol, UK), Dr Raghu Lingam (University of Bristol, UK), Dr Kate Northstone (University of Bristol, UK)
Title of project: 
Ophthalmic associations of Developmental Co-ordination Disorder.
Proposal summary: 

Is the prevalence of the following conditions increased in children aged 7 who concurrently meet the DSM-IV criteria for DCD, compared to those who do not?

a.Reduced stereoacuity

b.Best eye visual acuity 6/18 or worse

c.Abnormal motor and sensory fusion at near or distance

d.Strabismus

e.Refractive error

f.Inter-ocular difference in acuity or refraction

g.Decreased visuo-spatial ability (according to maternal questionnaire at age 13). The answers to these will inform clinically important questions such as:

If a patient is diagnosed with DCD is there an indication for referring them routinely to either an ophthalmologist or an orthoptist?

In any given patient with DCD what is the likelihood of them having one of the above ophthalmic conditions?

Could any of the ocular problems listed in question 1 be used as a risk marker for DCD?

Methods: The primary exposure variable will be the presence of DCD according to the DSM-IV criteria at age 7 Cross-tabulations, then Univariate and Multivariable linear regression or logistic regression models will be used to look at the associations between DCD and the listed ocular abnormalities accounting for potential confounding and mediating factors identified from the literature. Adjustment will be made for the bias introduced by missing data using multiple imputation by chained equation.

Date proposal received: 
Thursday, 6 October, 2011
Date proposal approved: 
Thursday, 6 October, 2011
Keywords: 
Development, Vision
Primary keyword: