B1255 - Childhood neurodevelopmental factors and risk of psychotic-like symptoms in 12-year-olds genetic variation and development - 06/10/2011

B number: 
B1255
Principal applicant name: 
Dr Mohajer A Hameed (Deakin University Burwood Campus Melbourne, Australia)
Co-applicants: 
Prof Andrew Lewis (Deakin University Burwood Campus Melbourne, Australia), Dr Marina Haywood (Deakin University Burwood Campus Melbourne, Australia), Dr Amirul Islam (Not used 0, Not used 0), Dr Stanley Zammit (University of Bristol, UK), Dr Sarah Sullivan (University of Bristol, UK)
Title of project: 
Childhood neurodevelopmental factors and risk of psychotic-like symptoms in 12-year-olds: genetic variation and development.
Proposal summary: 

Paper 1: Childhood Literacy skills and psychotic-like-symptoms in a non-clinical population at 12 years of age. (1) Are here any associations between the selected literacy skills (language and speech functioning domains) of a child at ages 7, 8, 9, 10, and PLIKS (interview) at the age of 13 in the ALSPAC cohort? (2) What are the significant predictors of PLIKS after adjustment for confounding variables if there is any? (3) Are any associations stronger with stricter definitions of PLIKS?

Paper 2: Childhood literacy, neurocognition, , motor functioning and psychotic-like-symptoms trajectories in a non-clinical population. (1) Are there any significant associations of literacy variables, neurocognitive variables and motor functioning with PLIKS trajectories? (2) Out of (a) literacy variables, (b) neurocognitive variables, and (c) motor skills, what are the significant predictor variables of PLIKS trajectories?

Paper 3: Genetic variation and childhood social cognition, neurocognitive functioning as predictors of psychotic-like symptoms . Aim: examine the joint relationship between two exposure variables, (a) child genotype and (b) social cognition, neurocognition in the prediction of PLIKS (mean age 12.9). specifically, the purpose is to examine the prediction of PLIKS at age 12 as a function of (a) social cognition measures, (b) neurocognition measures, and (c) genetic variation.

Date proposal received: 
Thursday, 6 October, 2011
Date proposal approved: 
Thursday, 6 October, 2011
Keywords: 
Genetics, Psychosis, Cognition, Cognitive Function, PLIKS
Primary keyword: