B1281 - Examining the mechanisms by which genetic variation contributes to adiposity how do BMI loci affect dietary intake - 15/12/2011

B number: 
B1281
Principal applicant name: 
Dr Rebecca Richmond (University of Bristol, UK)
Co-applicants: 
Dr Nic Timpson (University of Bristol, UK)
Title of project: 
Examining the mechanisms by which genetic variation contributes to adiposity: how do BMI loci affect dietary intake?
Proposal summary: 

Aims

  • To check the relationship between dietary intake and BMI/adiposity status in ALSPAC
  • To examine the specific relationships between confirmed BMI loci and adiposity in ALSPAC
  • To examine the relationships between confirmed BMI loci and dietary intake and to analyse the independent effects of the 32 BMI loci on specific patterns in dietary intake
  • To analyse the effect of these loci in aggregate and the specific patterns of dietary intake
  • To examine specific relationships between BMI loci, adiposity and activity levels in ALSPAC

Hypotheses

  • There will be a positive relationship between recorded dietary intake and BMI/adiposity status at age 10 in the cohort
  • There will be associations between genetic variation at the 32 adiposity loci and BMI/adiposity status at age 10 in the cohort
  • There will be associations between genetic variation at the 32 adiposity loci and patterns of dietary intake. These associations will be explored to find specific pathways to effect and effect sizes for the 32 BMI loci will be calculated e.g. per day calorie intake for a rare allele at given SNP
  • There will be relationships between groups of specific BMI loci and patterns of dietary intake
  • These relationships will be examined in the presence of suitable correction for mis-reporting of dietary intake and also in activity (taken from the age 11/13 acti-graph measurements)
Date proposal received: 
Thursday, 15 December, 2011
Date proposal approved: 
Thursday, 15 December, 2011
Keywords: 
Genetics, Obesity
Primary keyword: