TwinsUK is an international genomic epidemiology resource started in 1992. This Adult Twin Registry contains 11,000 volunteer population-representative twins with basic phenotypic information. 7,000 twins have both extensive phenotypic and genomic data, including 3000 individuals with next generation sequencing. This aims of this application are to:-

1) Maintain TwinsUK, including the core staff, twin register, and twin engagement, to facilitate use of the resource in ongoing and new projects.

2) Open and enhance the TwinsUK resource for the wider scientific community by inviting applications for new phenotypes and collecting and storing fibroblasts during a new data colletion sweep in 2013-2015.

3) Continue and improve ongoing access to data and samples from more than 20 years of TwinsUK collection. Extend the current model of supported access towards a full open accss model for TwinsUK data. This will expand on current work on the WT/MRC UK10K project (50 phenotypes with open access) to enable external academics maximal access to data already collected.

4) Further develop the resource by upgrading the extensive biobank of biological samples stored by TwinsUK into a robotic facility to ease sample availability under supported access, and ensure secure sample backup and replacement for sustainable long-term use.