B1375 - Identification of normal and at-risk trajectories of blood pressure in pregnancy in relation to offspring health - 24/05/2012
B number:
B1375
Principal applicant name:
Corrie Macdonald-Wallis (University of Bristol, UK)
Co-applicants:
Prof Debbie A Lawlor (University of Bristol, UK), Prof Kate Tilling (University of Bristol, UK)
Title of project:
Identification of normal and at-risk trajectories of blood pressure in pregnancy, in relation to offspring health.
Proposal summary:
Objectives:
1. To develop normal reference ranges (normograms) for blood pressure across pregnancy based on pre/early-pregnancy maternal risk factors, conditional on the first blood pressure measurement, and to assess the ability of deviations from these trajectories to predict PE, preterm birth and SGA.
2. To investigate associations of patterns of blood pressure change in pregnancy with offspring perinatal outcomes (preterm birth, birth weight and SGA) and cardiovascular risk factors, growth and changes in adiposity in the offspring during childhood and adolescence.
3. To identify maternal and fetal genetic variants related to blood pressure changes in pregnancy.
Date proposal received:
Thursday, 24 May, 2012
Date proposal approved:
Thursday, 24 May, 2012
Keywords:
Blood Pressure, Pregnancy
Primary keyword: