Plasma levels of testosterone and sex hormone-binding globulin are associated with risk of diabetes. Several cross-sectional studies have reported positive associations between exposures to endocrine disrupting chemicals (EDCs) with BMI or insulin resistance. There are no longitudinal studies, however, exploring associations of gestational concentrations of EDCs during pregnancy with endogenous sex hormones known to predict obesity. For this proposal we want to use data on concentrations of sex hormones and insulin resistance generated by Hany Lashen on a sample of girls at age 15 to explore associations with EDCs.

The goals of this proposal are to explore feasibility of testing study associations with current data and development of future studies on this topic.