Aims

We aim to phenotypically refine measures of adiposity and metabolism to encapture a number of individuals that may potentially be described as metabolically healthy obese or metabolically unhealthy non obese and to then explore the potential common genetic variants that are specifically associated with these disparate profiles in ALSPAC Children. We are interested in further analysing other cohorts (TWINS UK) for similarities in these disparities. We also aim to assess replication of our GWAS and to perform a Meta analysis to improve power of results.