B2034 - A large-scale haplotype reference resource UK10K - 20/06/2013
B number:
B2034
Principal applicant name:
Dr Richard Durbin (Wellcome Trust Sanger Institute, London, UK)
Co-applicants:
Dr Nic Timpson (University of Bristol, UK), Prof George Davey Smith (University of Bristol, UK), Dr Jonathan Marchini (University of Oxford, UK)
Title of project:
A large-scale haplotype reference resource (UK10K).
Proposal summary:
The aim is to bring together full genome genotype data from greater than 20,000 low coverage whole genome sequenced samples from multiple projects (all now in principle available), to construct a haplotype reference for imputation. The first phase, to be carried out during the next few months, is to evaluate different strategies for combining and using data for accuracy and practicality. Then in a second phase we would want to enable imputation by others for sample collections with genotype data. Here we just ask for permission for the first phase. Further discussion will be needed about how to establish access for the second phase.
Date proposal received:
Thursday, 20 June, 2013
Date proposal approved:
Thursday, 20 June, 2013
Keywords:
Genetics, Methods, UK10K
Primary keyword: