B2067 - Utilising multiple independent combinations of genetic variants to evaluate potential pleiotropy - 15/08/2013
B number:
B2067
Principal applicant name:
Dr Tom M Palmer (University of Warwick, UK)
Co-applicants:
Prof George Davey Smith (University of Bristol, UK), Dr Ian White (MRC Biostatistics Unit, University of Cambridge, UK)
Title of project:
Utilising multiple independent combinations of genetic variants to evaluate potential pleiotropy.
Proposal summary:
We aim to develop a method to investigate potential pleiotropy in causal estimates derived using the Mendelian randomization approach. The ALSPAC data will be used as an illustrative example.
Exposure: height, Outcome: FVC lung function (unadjusted for height), instrumental variables: 20 genotypes listed below.
Date proposal received:
Monday, 12 August, 2013
Date proposal approved:
Thursday, 15 August, 2013
Keywords:
Mendelian Randomisation
Primary keyword:
Genetics