B2067 - Utilising multiple independent combinations of genetic variants to evaluate potential pleiotropy - 15/08/2013

B number: 
B2067
Principal applicant name: 
Dr Tom M Palmer (University of Warwick, UK)
Co-applicants: 
Prof George Davey Smith (University of Bristol, UK), Dr Ian White (MRC Biostatistics Unit, University of Cambridge, UK)
Title of project: 
Utilising multiple independent combinations of genetic variants to evaluate potential pleiotropy.
Proposal summary: 

We aim to develop a method to investigate potential pleiotropy in causal estimates derived using the Mendelian randomization approach. The ALSPAC data will be used as an illustrative example.

Exposure: height, Outcome: FVC lung function (unadjusted for height), instrumental variables: 20 genotypes listed below.

Date proposal received: 
Monday, 12 August, 2013
Date proposal approved: 
Thursday, 15 August, 2013
Keywords: 
Mendelian Randomisation
Primary keyword: 
Genetics