B2096 - Relationship between nicotine metabolism rate as determined by CYP2A6 genotype and smoking patterns in adolescence - 24/10/2013

B number: 
B2096
Principal applicant name: 
Dr Meghan Chenoweth (University of Toronto, Canada)
Co-applicants: 
Prof Marcus Munafo (University of Bristol, UK), Dr Rachel Tyndale (University of Toronto, Canada), Dr Jon Heron (University of Bristol, UK)
Title of project: 
Relationship between nicotine metabolism rate, as determined by CYP2A6 genotype, and smoking patterns in adolescence.
Proposal summary: 

Aims:

1. Examine patterns of cigarette use across ages 13 to 21 years and identify sources of heterogeneity in smoking phenotypes

2. Identify relationships between CYP2A6 nicotine metabolism group and smoking patterns across ages 13 to 21 years

3. Compare the relative influence of CYP2A6 nicotine metabolism group on smoking initiation vs. smoking escalation across ages 13 to 21 years

Hypotheses:

Relative to normal CYP2A6 metabolizers, reduced CYP2A6 metabolizers will:

1. Escalate cigarette consumption faster in earlier adolescence

2. Escalate cigarette consumption slower in later adolescence/young adulthood

3. Have higher levels of cigarette consumption at earlier stages in adolescence

4. Have lower levels of cigarette consumption at later stages in adolescence/young adulthood

We also predict that there will be no association between CYP2A6 metabolism group and smoking initiation.

Date proposal received: 
Tuesday, 22 October, 2013
Date proposal approved: 
Thursday, 24 October, 2013
Keywords: 
Primary keyword: 
Smoking