B2111 - Identification of patterns of methylation associated with age at menarche - 28/11/2013
B number:
B2111
Principal applicant name:
Dr Cathy Elks (University of Cambridge, UK)
Co-applicants:
Dr Caroline Relton (University of Bristol, UK), Dr John Perry (University of Cambridge, UK), Ken Ong (University of Cambridge, UK)
Title of project:
Identification of patterns of methylation associated with age at menarche.
Proposal summary:
Aims:
1) To identify differentially methylated regions (DMRs) that are associated with age at menarche. This will be tested in both ALSPAC mothers using recalled age at menarche, and in young participants using DNA methylation measured at 15-17 years and age at menarche reported at the 21/22 year visit.
2) To explore whether identified DMRs are already apparent at birth, or if they are established over the course of childhood and adolescence.
3) To understand how common genetic variation underlies differences in methylation relating to menarche timing.
Date proposal received:
Monday, 18 November, 2013
Date proposal approved:
Thursday, 28 November, 2013
Keywords:
Puberty
Primary keyword:
Epigenetics