B2117 - Investigating the causal effect of maternal obesity on pregnancy outcomes using Mendelian Randomization in ALSPAC - 28/11/2013

B number: 
B2117
Principal applicant name: 
Dr Rebecca Richmond (University of Bristol, UK)
Co-applicants: 
Dr Abigail Fraser (University of Bristol, UK), Prof Debbie A Lawlor (University of Bristol, UK), Dr Nic Timpson (University of Bristol, UK), Prof George Davey Smith (University of Bristol, UK)
Title of project: 
Investigating the causal effect of maternal obesity on pregnancy outcomes using Mendelian Randomization in ALSPAC.
Proposal summary: 

Aims

To perform Mendelian randomization analyses to investigate the causal effect of maternal pre-pregnancy BMI on a number of pregnancy outcomes using genetic variants combined in a weighted allelic score. Other related exposures including maternal waist-hip ratio, maternal glycaemia and fatty acid profile will also be considered in an Mendelian randomization framework.

Date proposal received: 
Monday, 25 November, 2013
Date proposal approved: 
Thursday, 28 November, 2013
Keywords: 
Mendelian Randomisation
Primary keyword: 
Pregnancy