B2120 - Investigation of parent of origin effects in relation to DNA methylation - 05/12/2013

B number: 
B2120
Principal applicant name: 
Mr Hashem Shibab (University of Bristol, UK)
Co-applicants: 
Dr Tom Gaunt (University of Bristol, UK), Dr Caroline Relton (University of Bristol, UK), Prof George Davey Smith (University of Bristol, UK)
Title of project: 
Investigation of parent of origin effects in relation to DNA methylation.
Proposal summary: 

Aim:

1) identify novel parent of origin variants in relation to DNA methylation in ALSPAC;

2) investigate the effects of known/established parent of origin variants (related to common disease) in relation to DNA methylation in ALSPAC;

3) Investigate the relationship between genotype, methylation and phenotype to better understand parent-of-origin effects on phenotype.

Date proposal received: 
Thursday, 28 November, 2013
Date proposal approved: 
Thursday, 5 December, 2013
Keywords: 
Primary keyword: 
Epigenetics