B2126 - Nutrition and conduct problems The role of environmental risks and DNA methylation - 19/12/2013

B number: 
B2126
Principal applicant name: 
Dr Edward Barker (King's College London, UK)
Co-applicants: 
Dr Caroline Relton (University of Bristol, UK), Dr Jonathan Mill (King's College London, UK), Dr Henning Tiemeier (Erasmus University Medical Center, Rottterdam, the Netherlands, Europe), Dr Susan Ring (University of Bristol, UK)
Title of project: 
Nutrition and conduct problems: The role of environmental risks and DNA methylation.
Proposal summary: 

Aim 1. Does poor prenatal nutrition (i.e., macronutrients, micronutrients and/or omega 3 fatty acids) impact with DNA methylation at birth, and does continued poor nutrition impact DNA methylation in childhood?

Aim 2. Is the relationship between prenatal poor nutrition and early onset conduct problems greater for those children whose mothers were stressed and depressed?

Aim 3. Is the relationship between nutrition, the key risk factors and an early onset of conduct problems partially explained by DNA methylation?

Aim 4. Use of whole genome-wide epigenetic approaches to identify developmental inter-relationships beween maternal depression and unhealthy nutrition in the prenatal and postnatal periods.

Aim 5. Use of conventional Mendelian Randomization to assess causal relationships between nutrition factors (prenatal and postnatal) and the early onset of conduct problems.

Date proposal received: 
Thursday, 12 December, 2013
Date proposal approved: 
Thursday, 19 December, 2013
Keywords: 
Conduct Disorder , Epigenetics
Primary keyword: 
Nutrition