Aims

The aims of this study are as follows:

1. To conduct a meta- and mega-analysis genome-wide association study of psychotic experiences in adolescents and young adults by combining data from multiple samples including ALSPAC. Further analyses will investigate the effects by chromosome location and variant class, and explore gene-gene and gene-environment interactions in the combined datasets.

2. To test whether genes influencing risk for adult psychiatric conditions such as schizophrenia and bipolar disorder and major depression (using polygenic risk scores) are shared with those for psychotic experiences in adolescence and young adulthood in a dataset of the combined samples including ALSPAC.

3. To conduct genome-wide complex trait analyses (GCTA) of psychotic experiences in adolescents and young adults in the combined dataset in order to estimate the measured heritability of these trait experiences.