B2146 - Epigenetic variations of miRNAs are associated with hepatocellular carcinoma cancer susceptibility - 27/01/2014
B number:
B2146
Principal applicant name:
Dr Jiaping Chen (Nanjing Medical University, China, ROW)
Co-applicants:
Dr Caroline Relton (University of Bristol, UK)
Title of project:
Epigenetic variations of miRNAs are associated with hepatocellular carcinoma cancer susceptibility.
Proposal summary:
The objective of this project will be to identify DNA methylation differences inmiRNAsin apparently normal cells, which may increase the individual's likelihood of subsequently developinghepatocellular carcinoma. Identification of such links might provide a plausible biological mechanism by which life exposures could increaseHCCrisk and provide a rational basis for future dietary/environmental interventions aimed at reducing the development of abnormal DNA methylation and thus reducing the risk ofHCC.
Date proposal received:
Monday, 20 January, 2014
Date proposal approved:
Monday, 27 January, 2014
Keywords:
Cancer
Primary keyword:
Epigenetics