B2150 - Elucidating phenotype effects of genetic markers associated with ankylosing spondylitis in adolescents - 30/01/2014
B number:
B2150
Principal applicant name:
Dr Dave Evans (University of Bristol, UK)
Co-applicants:
Dr Veera Srividya Katikireddi (Royal Brisbane Hospital, ROW), Prof Mika Ala-Korpela (University of Oulu, Europe), Dr Jon Tobias (University of Bristol, UK)
Title of project:
Elucidating phenotype effects of genetic markers associated with ankylosing spondylitis in adolescents.
Proposal summary:
AIMS:
Specifically the primary objectives of this study are:
1) To determine if known genetic variants of Ankylosing Spondylitis (36 SNPs in total including SNP tagging HLA-B27 rs4349859) are associated with low back pain in adolescents aged 17 to 18 years in the population based birth cohort, ALSPAC.
2) To determine if a genetic risk score of the above variants is associated with low back pain in these adolescents at age 17 to 18 years.
3) To determine if known AS genetic variants (36 SNPs in total including SNP tagging HLA-B27 rs4349859) and/or the AS genetic risk score are associated with any of 216 metabolonomic variables, CRP and IL6.
Date proposal received:
Thursday, 23 January, 2014
Date proposal approved:
Thursday, 30 January, 2014
Keywords:
Arthritis, Genetics, Pain
Primary keyword:
Metabolomics