B2173 - Hypermobility in young adults - 20/02/2014

B number: 
B2173
Principal applicant name: 
Dr Emma Clark (Univeristy of Bristol, UK)
Co-applicants: 
Prof Shea Palmer (University of the West of England (UWE), Bristol), Dr Kate Northstone (University of Bristol, UK), Dr Jon Tobias (University of Bristol, UK)
Title of project: 
Hypermobility in young adults.
Proposal summary: 

Aims

Our over-arching objectives are to further study the basic epidemiology of hypermobility in young adults, and to extend our investigation into the relationship between hypermobility, pain and obesity. Our specific aims are:

1. To produce the first population-based data on the change in prevalence of joint hypermobility between aged 14 and 24. Novel epidemiology of joint hypermobility according to anatomical site, gender, socioeconomics and other basics.

2. To further study the association between hypermobility and pain cross-sectionally (both measured at aged 24) and prospectively (hypermobility at aged 14 with pain at aged 24).

3. To extend the investigation into the associations between hypermobility, pain and obesity by using pQCT measures of fat as well as Mendelian Randomisation (we previously only looked at DXA measures of fat)

4. To investigate the associations between hypermobility and additional symptoms including functional bowel disorders, fatigue and other features of autonomic dysfunction.

Date proposal received: 
Tuesday, 18 February, 2014
Date proposal approved: 
Thursday, 20 February, 2014
Keywords: 
Primary keyword: 
Joints