B2196 - Association of maternal and pre-pubertal 25-Hydroxyvitamin D with post-pubertal Anti-Mllerian Hormone in off-springs - 13/03/2014

B number: 
B2196
Principal applicant name: 
Dr Stamatina Iliodromiti (University of Glasgow, UK)
Co-applicants: 
Dr Abigail Fraser (University of Bristol, UK), Prof Debbie A Lawlor (University of Bristol, UK), Prof Scott Nelson (University of Glasgow, UK)
Title of project: 
Association of maternal and pre-pubertal 25-Hydroxyvitamin D with post-pubertal Anti-M?llerian Hormone in off-springs.
Proposal summary: 

Aims

The aims of the study are:

(1) to investigate the prospective association between 25(OH)D concentrations at the mean age of 9.9 years and serum AMH at the mean age of 15 years in a large cohort (N=5,080 with levels of 25(OH)D at age of 7,9, or 11 and N = 3,474 with measured levels AMH at the age of 15 years, once data available we will estimate the exact number of eligible pairs for this analysis).

(2) to investigate the prospective association between maternal pregnancy 25(OH)D concentrations and offspring AMH at a mean age of 15 years in a large cohort (N =7,714 mothers with pregnancy 25(OH)D results and N = 3,474 with measured levels AMH at the age of 15 years).

Depending on the results relating to these two primary aims we will further examine whether any association of maternal pregnancy 25(OH)D with offspring AMH at mean age 15 years is mediated by offspring's own pre-pubertal 25(OH)D.

Date proposal received: 
Thursday, 6 March, 2014
Date proposal approved: 
Thursday, 13 March, 2014
Keywords: 
Endocrine, Reproductive Health
Primary keyword: 
Vitamin D