OBJECTIVES (note these will be achieved within the collaboration of greater than 50 studies and greater than 500,000 participants; ALSPAC will contribute to some but not all and for each objective more than one study will always contribute)

1a. To determine how metabolomic profiles change with age from birth through to old age.

1b. To explore the extent to which risk factors from across the life course (diet, physical activity, alcohol, adiposity) alter general age related trajectories

2. To determine the extent to which blood-based metabolic profiles (assessed at different ages), in addition to clinical characteristics, improve stratification of adults into different levels of risk for cardiovascular disease, type 2 diabetes and dementia

3a. To determine the effect of risk factors, such as greater adiposity, low levels of physical activity, poor diet and excessive alcohol consumption, on metabolic profiles at different ages.

3b. To determine the effect of different blood-based metabolic profiles (assessed at different ages) on subsequent risk of adverse cardiometabolic risk factors, CHD, stroke, type 2 diabetes, lower cognitive function and dementia.

3c. To determine the role of blood-based metabolic profiles (assessed at different ages) in the causal pathway between upstream risk factors (such as greater adiposity, low levels of physical activity, poor diet and excessive alcohol consumption) and subsequent cardiometabolic, cognitive and ageing outcomes