The project aims to identify genetic and environmental factors associated with failure to acquire expected peakk lung function in early adulthood as a prequel to chronic obstructive pulmonary disease, to specify functional and inflammatory outcomes of well-characterised asthma and wheezing phenotypes through chidhood and adolescence, and to test a novel device for measuring lung function using a mobile phone app in a the context of population-based data collection.

The project aims are three-fold:

1. To extend measurement of lung function in the original ALSAC cohort to its physiological peak in early adultood; completing the trajectory of lung function accural during childhood

2. To conduct a detailed assessment of the outcomes adn endotypes of longitudinal chidhood wheezing phenotypes by recruiting a sub-sample for:

(a) Detailed lung function measurements in a respiratory laboratory

(b) Standardised exercise challenge and cardiorespiratory perfomance (VO2max)

(c) Detailed measures of airway inflammation (Exhaled NO, induced sputum collection)

3. To conduct a feasibility and validation study of the use or a novel mobile-phone based lung function app (SpiroSmart) for near-subject testing in a smapel of participants that have had laboratory measurements as part of Aim (1).