B2223 - Chronic irritability in ADHD Examining clinical and genetic links with depression - 10/04/2014
B number:
B2223
Principal applicant name:
Olga Eyre (University of Cardiff, UK)
Co-applicants:
Prof Anita Thapar (University of Cardiff, UK), Dr Stephan Collishaw (University of Cardiff, UK), Prof George Davey Smith (Univeristy of Bristol, UK), Dr Evie Stergiakouli (University of Bristol, UK)
Title of project:
Chronic irritability in ADHD: Examining clinical and genetic links with depression
Proposal summary:
Aims:
The proposed project aims to use data from the ASLPAC study to test whether:
1. In children with ADHD, symptoms of irritability are associated with an increased risk of depressive symptoms in adolescence.
2. In children with neurodevelopmental disorders (including ADHD, Intellectual Disability (ID), Autistic Spectrum Disorder (ASD), Communication Disorders, Motor Disorders), symptoms of irritability are associated with an increased risk of depressive symptoms in adolescence.
3. In children with ADHD and other neurodevelopmental disorders, symptoms of irritability index higher rates of family history of depression and increased genetic risk for depression.
Date proposal received:
Tuesday, 8 April, 2014
Date proposal approved:
Thursday, 10 April, 2014
Keywords:
Depression, Genetics
Primary keyword:
ADHD