B2230 - DNA methylation patterns in genes controlling vitamin D metabolism a lifespan approach - 01/05/2014
B number:
B2230
Principal applicant name:
Dr Andrea Darling (University of Surrey, UK)
Co-applicants:
Prof Susan Lanham-New (University of Surrey, UK), Dr Kathryn Hart (University of Surrey, UK), Dr Kourosh Ahmadi (University of Surrey, UK)
Title of project:
DNA methylation patterns in genes controlling vitamin D metabolism ? a lifespan approach.
Proposal summary:
Aims:
1 Assess the changes that occur in DNA methylation status over the life span for vitamin D relevant genes. Including, how does early life methylation status vary from that of later life?
2.What are the implications of these changes for vitamin D status and health outcomes over the lifespan?
3.Do any of these methylation changes correlate with traditional risk factors for vitamin D deficiency (e.g. ethnicity, age, obesity) and if so how?
4.How do people who respond well to vitamin D supplements differ in methylation status (for vitamin D related genes) from those who do not respond well?
Date proposal received:
Monday, 28 April, 2014
Date proposal approved:
Thursday, 1 May, 2014
Keywords:
Vitamin D
Primary keyword:
Epigenetics