B2246 - Genetic determinants of liver function and their relationship to cardiometabolic health - 29/05/2014
B number:
B2246
Principal applicant name:
Prof Debbie A Lawlor (University of Bristol, UK)
Co-applicants:
Dr Maneka De Silva (University of Bristol, UK), Dr Tom Gaunt (University of Bristol, UK)
Title of project:
Genetic determinants of liver function and their relationship to cardiometabolic health.
Proposal summary:
The broad aims of our study are as follows;
1.Examine the association of metabochip variants with ALP, ALT, AST, GGT, Bilirubin and Albumin to determine whether (i) these replicate published GWAS findings and (ii) identify new variants
2.Undertake Mendelian randomization study of the causal effect of ALP, ALT, AST, GGT, Bilirubin and Albumin (markers of liver damage) with CHD, stroke, type 2 diabetes events and with risk factors for these outcomes (i.e: fasting glucose, fasting insulin, LDL, HDL, Triglycerides, total cholesterol, SBP and DBP)
Date proposal received:
Wednesday, 28 May, 2014
Date proposal approved:
Thursday, 29 May, 2014
Keywords:
Cardiovascular
Primary keyword:
Mendelian Randomisation